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J Cosmet Med 2018; 2(2): 69-75

Published online December 31, 2018

https://doi.org/10.25056/JCM.2018.2.2.69

Development of an effective formulation for an acne treatment cream with Ocimum basilicum using invasomes

Hyun Jee Han , MS

MSc Pharmaceutics, School of Pharmacy, University College London, London, United Kingdom

Correspondence to :
Hyun Jee Han, E-mail: sarah96120@gmail.com, ORCID: https://orcid.org/0000-0002-0068-8162

Received: August 30, 2018; Revised: October 26, 2018; Accepted: October 30, 2018

© Korean Society of Korean Cosmetic Surgery

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Cosmeceutical formulations of Ocimum basilicum are designed in an effective base to medicate topical acne-causing inflammation using an advanced drug delivery system. Acne vulgaris is a common disease found not only in young people but also in adults. The present study suggests the use of O. basilicum as a cream for the treatment of acne. Anti-acne creams formulated from crude herbal extracts have long been used for their antimicrobial and antioxidant activities to prevent the inflammation that causes acneiform eruption. This study proposes that, along with the formulation of a micro-emulsion, the use of invasomes will offer an effective advanced drug delivery system that promises improved efficacy and stability in treating acne with O. basilicum.

Keywords: acne vulgaris, cosmeceuticals, facial cream, invasomes, micro-emulsion, Ocimum basilicum

  1. Jackson-Cannady A. What are cosmeceuticals? [Internet]. New York: WebMD, 2012 [cited 2018 Nov 9].
    Available from: https://www.webmd.com/beauty/features/what-are-cosmeceuticals.
  2. Alqasoumi SI, Al-Dosari MS, AlSheikh AM, Abdel-Kader MS. Evaluation of the hepatoprotective effect of Fumaria parviflora and Momordica balsamina from Saudi folk medicine against experimentally induced liver injury in rats. Res J Med Plant 2009;3:9-15.
    CrossRef
  3. Gupta VK, Sharma SK. Plants as natural antioxidants. Nat Prod Radiance 2006;5:326-34.
  4. Huang HY, Huang JJ, Tso TK, Tsai YC, Chang CK. Antioxidant and angiotension-converting enzyme inhibition capacities of various parts of Benincasa hispida (wax gourd). Nahrung 2004;48:230-3.
    Pubmed CrossRef
  5. Chanchal D, Swarnlata S. Novel approaches in herbal cosmetics. J Cosmet Dermatol 2008;7:89-95.
    Pubmed CrossRef
  6. Aslam I, Fleischer A, Feldman S. Emerging drugs for the treatment of acne. Expert Opin Emerg Drugs 2015;20:91-101.
    Pubmed CrossRef
  7. Cosmetiqo. Basil - skin care benefits [Internet]. COSMETIQO, 2017 [cited 2018 Nov 9].
    Available from: https://cosmetiqo.com/anti-aging-ingredients/basil-skin-care-benefits/.
  8. Bihari GC, Manaswini B, Prabhat J, Kumar TS. Pharmacognostical and phytochemical investigation of various tulsi plants available in South Eastern Odisha. Int J Res Pharm Biomed Sci 2011;2:605-10.
  9. Niture SK, Rao US, Srivenugopal KS. Chemopreventative strategies targeting the MGMT repair protein: augmented expression in human lymphocytes and tumor cells by ethanolic and aqueous extracts of several Indian medicinal plants. Int J Oncol 2006;29:1269-78.
    CrossRef
  10. Sabale V, Kunjwani H, Sabale P. Formulation and in vitro evaluation of the topical antiageing preparation of the fruit of Benincasa hispida. J Ayurveda Integr Med 2011;2:124-8.
    Pubmed KoreaMed CrossRef
  11. Peirce A; American Pharmaceutical Association. The American Pharmaceutical Association practical guide to natural medicines. New York: Morrow; 1999. 728 p.
    KoreaMed
  12. Hobbs C. Herbal remedies for dummies. Foster City, CA: IDG Books Worldwide; 1998. 352 p.
  13. Singh J. Basil seeds (Sabja or Tukmaria seeds) benefits & side effects [Internet]. Punjab: Ayur Times, 2018 [cited 2018 Nov 10].
    Available from: https://www.ayurtimes.com/basil-seeds-sabja-tukmaria-seeds-benefits-side-effects/.
  14. Chiu A, Kimball AB. Topical vitamins, minerals and botanical ingredients as modulators of environmental and chronological skin damage. Br J Dermatol 2003;149:681-91.
    Pubmed CrossRef
  15. Khare CP. Indian medicinal plants: an illustrated dictionary. Berlin: Springer; 2007.
    KoreaMed
  16. Rasul A, Akhtar N. Formulation and in vivo evaluation for anti-aging effects of an emulsion containing basil extract using non- invasive biophysical techniques. Daru 2011;19:34450.
  17. Dasgupta T, Rao AR, Yadava PK. Chemomodulatory efficacy of Basil leaf (Ocimum basilicum) on drug metabolizing and antioxidant enzymes, and on carcinogen-induced skin and forestomach papillomagenesis. Phytomedicine 2004;11:13951.
    Pubmed CrossRef
  18. Kumar R, Shukla SK, Qidwai A, Pandey A, Dikshit A. Pharmacological studies of Ocimum basilicum L. Indo Am Pharm Sci 2017;4:3576-82.
  19. Shafique M, Khan SJ, Khan NH. Study of antioxidant and antimicrobial activity of sweet basil (Ocimum basilicum) essential oil. Pharmacologyonline 2011;1:105-11.
  20. Kashyap CP, Ranjeet K, Vikrant A, Vipin K. Therapeutic potency of Ocimum kilimandscharicumGuerke - a review. Glob J Pharmacol 2011;5:191-200.
  21. Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med 2010;49:1603-16.
    Pubmed KoreaMed CrossRef
  22. Saint-Leger D, Bague A, Lefebvre E, Cohen E, Chivot M. A possible role for squalene in the pathogenesis of acne. II. In vivo study of squalene oxides in skin surface and intra-comedonal lipids of acne patients. Br J Dermatol 1986;114:543-52.
    Pubmed CrossRef
  23. Bunrathep S, Palanuvej C, Ruangrungsi N. Chemical compositions and antioxidative activities of essential oils from four Ocimum species endemic to Thailand. J Health Res 2007;21:201-6.
  24. Particle Sciences. Emulsions and emulsification [Internet]. Bethlehem, PA: Particle Sciences, 2009 [cited 2018 Nov 10].
    Available from: https://www.particlesciences.com/news/technical-briefs/2009/emulsions-and-emulsification.html.
  25. Tadros TF. Emulsion formation and stability. Weinheim:Wiley-VCH; 2013. 270 p.
    CrossRef
  26. Alexander AE, Johnson P. Colloid science. Oxford: Clarendon Press; 1949.
  27. Bimakr M, Rahman RA, Ganjloo A, Taip FS, Adzahan NM, Sarker MZI. Characterization of valuable compounds from winter melon (Benincasa hispida (Thunb.) Cogn.) seeds using supercritical carbon dioxide extraction combined with pressure swing technique. Food Bioproc Tech 2016;9:396-406.
    CrossRef
  28. Viyoch J, Pisutthanan N, Faikreua A, Nupangta K, Wangtorpol K, Ngokkuen J. Evaluation of in vitro antimicrobial activity of Thai basil oils and their micro-emulsion formulas against Propionibacterium acnes. Int J Cosmet Sci 2006;28:125-33.
    Pubmed CrossRef
  29. Sarker SD, Latif Z, Gray AI. Natural product isolation. In: Sarker SD, Latif Z, Gray AI, editors. Natural products isolation. 2nd ed. Totowa, NJ: Humana Press; 2005. p. 1-25.
    CrossRef
  30. Bilal A, Jahan N, Ahmed A, Bilal SN, Habib S, Hajra S. Phytochemical and pharmacological studies on Ocimum basilicum linn - a review. Int J Cur Res Rev 2012;4:73-83.
  31. Orafidiya LO, Oyedele AO, Shittu AO, Elujoba AA. The formulation of an effective topical antibacterial product containing Ocimum gratissimum leaf essential oil. Int J Pharm 2001;224:177-83.
    CrossRef
  32. Engels T, F?rster T, von Rybinski W. The influence of coemulsifier type on the stability of oil-in-water emulsions. Colloids Surf A Physicochem Eng Asp 1995;99:141-9.
    CrossRef
  33. Garrett ER. Stability of oil-in-water emulsions. J Pharm Sci 1965;54:1557-70.
    CrossRef
  34. Sahu G, Sahu S, Sharma H, Kumar Jha A. A review of current and novel trends for anti-ageing formulation. Int J Pharm Chem Biol Sci 2014;4:118-25.
  35. Monteiro N, Martins A, Reis RL, Neves NM. Liposomes in tissue engineering and regenerative medicine. J R Soc Interface 2014;11:20140459.
    Pubmed KoreaMed CrossRef
  36. Prasanthi D, Lakshmi PK. Vesicles - mechanism of transdermal permeation: a review. Asian J Pharm Clin Res 2012;5:18-25.
  37. Badran MM, Kuntsche J, Fahr A. Skin penetration enhancement by a microneedle device (Dermaroller) in vitro: dependency on needle size and applied formulation. Eur J Pharm Sci 2009;36:511-23.
    Pubmed CrossRef
  38. Quinn PJ. The effect of tocopherol on the structure and permeability of phosphatidylcholine liposomes. J Control Release 2012;160:158-63.
    Pubmed CrossRef
  39. Florence AT, Whitehill D. Stabilization of water/oil/water multiple emulsions by polymerization of the aqueous phases. J Pharm Pharmacol 1982;34:687-91.
    CrossRef
  40. Matiz G, Osorio MR, Camacho F, Atencia M, Herazo J. [Effectiveness of antimicrobial formulations for acne based on orange (Citrus sinensis) and sweet basil (Ocimum basilicum L) essential oils]. Biomedica 2012;32:125-33. Spanish.
    Pubmed

Article

Review Article

J Cosmet Med 2018; 2(2): 69-75

Published online December 31, 2018 https://doi.org/10.25056/JCM.2018.2.2.69

Copyright © Korean Society of Korean Cosmetic Surgery.

Development of an effective formulation for an acne treatment cream with Ocimum basilicum using invasomes

Hyun Jee Han , MS

MSc Pharmaceutics, School of Pharmacy, University College London, London, United Kingdom

Correspondence to:Hyun Jee Han, E-mail: sarah96120@gmail.com, ORCID: https://orcid.org/0000-0002-0068-8162

Received: August 30, 2018; Revised: October 26, 2018; Accepted: October 30, 2018

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Cosmeceutical formulations of Ocimum basilicum are designed in an effective base to medicate topical acne-causing inflammation using an advanced drug delivery system. Acne vulgaris is a common disease found not only in young people but also in adults. The present study suggests the use of O. basilicum as a cream for the treatment of acne. Anti-acne creams formulated from crude herbal extracts have long been used for their antimicrobial and antioxidant activities to prevent the inflammation that causes acneiform eruption. This study proposes that, along with the formulation of a micro-emulsion, the use of invasomes will offer an effective advanced drug delivery system that promises improved efficacy and stability in treating acne with O. basilicum.

Keywords: acne vulgaris, cosmeceuticals, facial cream, invasomes, micro-emulsion, Ocimum basilicum

References

  1. Jackson-Cannady A. What are cosmeceuticals? [Internet]. New York: WebMD, 2012 [cited 2018 Nov 9]. Available from: https://www.webmd.com/beauty/features/what-are-cosmeceuticals.
  2. Alqasoumi SI, Al-Dosari MS, AlSheikh AM, Abdel-Kader MS. Evaluation of the hepatoprotective effect of Fumaria parviflora and Momordica balsamina from Saudi folk medicine against experimentally induced liver injury in rats. Res J Med Plant 2009;3:9-15.
    CrossRef
  3. Gupta VK, Sharma SK. Plants as natural antioxidants. Nat Prod Radiance 2006;5:326-34.
  4. Huang HY, Huang JJ, Tso TK, Tsai YC, Chang CK. Antioxidant and angiotension-converting enzyme inhibition capacities of various parts of Benincasa hispida (wax gourd). Nahrung 2004;48:230-3.
    Pubmed CrossRef
  5. Chanchal D, Swarnlata S. Novel approaches in herbal cosmetics. J Cosmet Dermatol 2008;7:89-95.
    Pubmed CrossRef
  6. Aslam I, Fleischer A, Feldman S. Emerging drugs for the treatment of acne. Expert Opin Emerg Drugs 2015;20:91-101.
    Pubmed CrossRef
  7. Cosmetiqo. Basil - skin care benefits [Internet]. COSMETIQO, 2017 [cited 2018 Nov 9]. Available from: https://cosmetiqo.com/anti-aging-ingredients/basil-skin-care-benefits/.
  8. Bihari GC, Manaswini B, Prabhat J, Kumar TS. Pharmacognostical and phytochemical investigation of various tulsi plants available in South Eastern Odisha. Int J Res Pharm Biomed Sci 2011;2:605-10.
  9. Niture SK, Rao US, Srivenugopal KS. Chemopreventative strategies targeting the MGMT repair protein: augmented expression in human lymphocytes and tumor cells by ethanolic and aqueous extracts of several Indian medicinal plants. Int J Oncol 2006;29:1269-78.
    CrossRef
  10. Sabale V, Kunjwani H, Sabale P. Formulation and in vitro evaluation of the topical antiageing preparation of the fruit of Benincasa hispida. J Ayurveda Integr Med 2011;2:124-8.
    Pubmed KoreaMed CrossRef
  11. Peirce A; American Pharmaceutical Association. The American Pharmaceutical Association practical guide to natural medicines. New York: Morrow; 1999. 728 p.
    KoreaMed
  12. Hobbs C. Herbal remedies for dummies. Foster City, CA: IDG Books Worldwide; 1998. 352 p.
  13. Singh J. Basil seeds (Sabja or Tukmaria seeds) benefits & side effects [Internet]. Punjab: Ayur Times, 2018 [cited 2018 Nov 10]. Available from: https://www.ayurtimes.com/basil-seeds-sabja-tukmaria-seeds-benefits-side-effects/.
  14. Chiu A, Kimball AB. Topical vitamins, minerals and botanical ingredients as modulators of environmental and chronological skin damage. Br J Dermatol 2003;149:681-91.
    Pubmed CrossRef
  15. Khare CP. Indian medicinal plants: an illustrated dictionary. Berlin: Springer; 2007.
    KoreaMed
  16. Rasul A, Akhtar N. Formulation and in vivo evaluation for anti-aging effects of an emulsion containing basil extract using non- invasive biophysical techniques. Daru 2011;19:34450.
  17. Dasgupta T, Rao AR, Yadava PK. Chemomodulatory efficacy of Basil leaf (Ocimum basilicum) on drug metabolizing and antioxidant enzymes, and on carcinogen-induced skin and forestomach papillomagenesis. Phytomedicine 2004;11:13951.
    Pubmed CrossRef
  18. Kumar R, Shukla SK, Qidwai A, Pandey A, Dikshit A. Pharmacological studies of Ocimum basilicum L. Indo Am Pharm Sci 2017;4:3576-82.
  19. Shafique M, Khan SJ, Khan NH. Study of antioxidant and antimicrobial activity of sweet basil (Ocimum basilicum) essential oil. Pharmacologyonline 2011;1:105-11.
  20. Kashyap CP, Ranjeet K, Vikrant A, Vipin K. Therapeutic potency of Ocimum kilimandscharicumGuerke - a review. Glob J Pharmacol 2011;5:191-200.
  21. Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Oxidative stress, inflammation, and cancer: how are they linked? Free Radic Biol Med 2010;49:1603-16.
    Pubmed KoreaMed CrossRef
  22. Saint-Leger D, Bague A, Lefebvre E, Cohen E, Chivot M. A possible role for squalene in the pathogenesis of acne. II. In vivo study of squalene oxides in skin surface and intra-comedonal lipids of acne patients. Br J Dermatol 1986;114:543-52.
    Pubmed CrossRef
  23. Bunrathep S, Palanuvej C, Ruangrungsi N. Chemical compositions and antioxidative activities of essential oils from four Ocimum species endemic to Thailand. J Health Res 2007;21:201-6.
  24. Particle Sciences. Emulsions and emulsification [Internet]. Bethlehem, PA: Particle Sciences, 2009 [cited 2018 Nov 10]. Available from: https://www.particlesciences.com/news/technical-briefs/2009/emulsions-and-emulsification.html.
  25. Tadros TF. Emulsion formation and stability. Weinheim:Wiley-VCH; 2013. 270 p.
    CrossRef
  26. Alexander AE, Johnson P. Colloid science. Oxford: Clarendon Press; 1949.
  27. Bimakr M, Rahman RA, Ganjloo A, Taip FS, Adzahan NM, Sarker MZI. Characterization of valuable compounds from winter melon (Benincasa hispida (Thunb.) Cogn.) seeds using supercritical carbon dioxide extraction combined with pressure swing technique. Food Bioproc Tech 2016;9:396-406.
    CrossRef
  28. Viyoch J, Pisutthanan N, Faikreua A, Nupangta K, Wangtorpol K, Ngokkuen J. Evaluation of in vitro antimicrobial activity of Thai basil oils and their micro-emulsion formulas against Propionibacterium acnes. Int J Cosmet Sci 2006;28:125-33.
    Pubmed CrossRef
  29. Sarker SD, Latif Z, Gray AI. Natural product isolation. In: Sarker SD, Latif Z, Gray AI, editors. Natural products isolation. 2nd ed. Totowa, NJ: Humana Press; 2005. p. 1-25.
    CrossRef
  30. Bilal A, Jahan N, Ahmed A, Bilal SN, Habib S, Hajra S. Phytochemical and pharmacological studies on Ocimum basilicum linn - a review. Int J Cur Res Rev 2012;4:73-83.
  31. Orafidiya LO, Oyedele AO, Shittu AO, Elujoba AA. The formulation of an effective topical antibacterial product containing Ocimum gratissimum leaf essential oil. Int J Pharm 2001;224:177-83.
    CrossRef
  32. Engels T, F?rster T, von Rybinski W. The influence of coemulsifier type on the stability of oil-in-water emulsions. Colloids Surf A Physicochem Eng Asp 1995;99:141-9.
    CrossRef
  33. Garrett ER. Stability of oil-in-water emulsions. J Pharm Sci 1965;54:1557-70.
    CrossRef
  34. Sahu G, Sahu S, Sharma H, Kumar Jha A. A review of current and novel trends for anti-ageing formulation. Int J Pharm Chem Biol Sci 2014;4:118-25.
  35. Monteiro N, Martins A, Reis RL, Neves NM. Liposomes in tissue engineering and regenerative medicine. J R Soc Interface 2014;11:20140459.
    Pubmed KoreaMed CrossRef
  36. Prasanthi D, Lakshmi PK. Vesicles - mechanism of transdermal permeation: a review. Asian J Pharm Clin Res 2012;5:18-25.
  37. Badran MM, Kuntsche J, Fahr A. Skin penetration enhancement by a microneedle device (Dermaroller) in vitro: dependency on needle size and applied formulation. Eur J Pharm Sci 2009;36:511-23.
    Pubmed CrossRef
  38. Quinn PJ. The effect of tocopherol on the structure and permeability of phosphatidylcholine liposomes. J Control Release 2012;160:158-63.
    Pubmed CrossRef
  39. Florence AT, Whitehill D. Stabilization of water/oil/water multiple emulsions by polymerization of the aqueous phases. J Pharm Pharmacol 1982;34:687-91.
    CrossRef
  40. Matiz G, Osorio MR, Camacho F, Atencia M, Herazo J. [Effectiveness of antimicrobial formulations for acne based on orange (Citrus sinensis) and sweet basil (Ocimum basilicum L) essential oils]. Biomedica 2012;32:125-33. Spanish.
    Pubmed

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