Original Article
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J Cosmet Med 2023; 7(1): 25-28
Published online June 30, 2023
Anti-inflammatory effects of ethanolic extract of Annona muricata
Yun-Mi Shin 
, PhD, You-Jeong Kim , PhD
Department of Associate Degree of Cosmetology, Yeoju Institute of Technology, Yeoju, Rep. of Korea
Correspondence to :
Yun-Mi Shin
E-mail: soso85@naver.com
© Korean Society of Korean Cosmetic Surgery & Medicine
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Background: Graviola (Annona muricata) is known to have a superior cancer cell killing effect than adriamycin, a chemical drug, and is used in hospitals. Check to see if it actually has an anti-inflammatory effect on the skin.
Objective: This study was conducted to assess the anti-inflammatory and molecular effects of A. muricata leaf extract to evaluate its potency as a cosmetic ingredient and value in the cosmetic industry.
Methods: The anti-inflammatory effects of A. muricata were evaluated using an ethanolic extract of its dried leaves. To assess the inhibitory effects of A. muricata extract on nitric oxide (NO) production, the amount of NO produced in RAW 264.7 cells induced by lipopolysaccharides (LPS), an inflammatory mediator, was measured.
Results: The experiment using the A. muricata leaf extract did not show a significant level of cytotoxicity at all concentration of the extract, and the survival rate of RAW 264.7 cells was low only at high concentrations of the extract. Assessment of the antiinflammatory effects of A. muricata leaf extract showed that a significant amount of NO production was inhibited in the cells compared to that when the leaf extract was incubated with LPS.
Conclusion: A. muricata leaf extract would be an excellent candidate as a cosmetic ingredient with its anti-inflammatory properties and other functions.
Keywords: Annona muricata, anti-inflammatory, cosmetic ingredients, dried graviola leaves, graviola
Fig. 1.Effect of Annona muricata L extract on cell viability in RAW 264.7 cells. Values represent the mean±standard deviation of three measurements.
- You S, Moon J. Study on the whitening effect and deterrent effect on gene expression of MMP-1 in wheat sprout extracts. J Korean Oil Chem Soc 2016;33:13-22.
- Oh SY. Pay attention to YOLO’s life. Excell Mark Cust 2017;51: 52-7.
- Kwon MJ, Moon JS, Choi EY. Development of preservatives for cosmetics using herbal extracts. J Korean Soc Cosmetol 2015; 21:347-56.
- Whang WK, Lee YA. Study about the natural ingredient cosmetics purchase toward the consciousness of LOHAS and socio-populational status. Asian J Beauty Cosmetol 2010;8:191-200.
- Shim SB. The study of characteristics of cosmetic powder by using various grinding mill. JKAIS 2008;9:500-7.
- Lee KO, Lee SH. The effects of skin treatment of Kumsong (Sciadopitys verticillata) extracts. J Korean Soc Cosmetol 2007;13:1185-95.
- Jeong DH, Kang BK, Kim KBWR, Kim MJ, Ahn DH. Antiinflammatory activity of Sargassum micracanthum water extract. J Appl Biol Chem 2014;57:227-34.
- Yoon YI, Chung MY, Hwang JS, Goo TW, Ahn MY, Lee YB, et al. Anti-inflammatory effect of Oxya chinensis sinuosa ethanol extract in LPS-induced RAW 264.7 cells. J Life Sci 2014;24: 370-6.
- Cho EJ, Lee JH, Sung NY, Byun EH. Anti-Inflammatory effects of Annona muricata leaf ethanol extracts. J Korean Soc Food Sci Nutr 2017;46:681-7.
- Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 1982;126:131-8.
- Bredt DS, Snyder SH. Transient nitric oxide synthase neurons in embryonic cerebral cortical plate, sensory
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Original Article
J Cosmet Med 2023; 7(1): 25-28
Published online June 30, 2023 https://doi.org/10.25056/JCM.2023.7.1.25
Copyright © Korean Society of Korean Cosmetic Surgery & Medicine.
Anti-inflammatory effects of ethanolic extract of Annona muricata
Yun-Mi Shin , PhD, You-Jeong Kim , PhD
Department of Associate Degree of Cosmetology, Yeoju Institute of Technology, Yeoju, Rep. of Korea
Correspondence to:Yun-Mi Shin
E-mail: soso85@naver.com
This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Graviola (Annona muricata) is known to have a superior cancer cell killing effect than adriamycin, a chemical drug, and is used in hospitals. Check to see if it actually has an anti-inflammatory effect on the skin.
Objective: This study was conducted to assess the anti-inflammatory and molecular effects of A. muricata leaf extract to evaluate its potency as a cosmetic ingredient and value in the cosmetic industry.
Methods: The anti-inflammatory effects of A. muricata were evaluated using an ethanolic extract of its dried leaves. To assess the inhibitory effects of A. muricata extract on nitric oxide (NO) production, the amount of NO produced in RAW 264.7 cells induced by lipopolysaccharides (LPS), an inflammatory mediator, was measured.
Results: The experiment using the A. muricata leaf extract did not show a significant level of cytotoxicity at all concentration of the extract, and the survival rate of RAW 264.7 cells was low only at high concentrations of the extract. Assessment of the antiinflammatory effects of A. muricata leaf extract showed that a significant amount of NO production was inhibited in the cells compared to that when the leaf extract was incubated with LPS.
Conclusion: A. muricata leaf extract would be an excellent candidate as a cosmetic ingredient with its anti-inflammatory properties and other functions.
Keywords: Annona muricata, anti-inflammatory, cosmetic ingredients, dried graviola leaves, graviola
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References
- You S, Moon J. Study on the whitening effect and deterrent effect on gene expression of MMP-1 in wheat sprout extracts. J Korean Oil Chem Soc 2016;33:13-22.
- Oh SY. Pay attention to YOLO’s life. Excell Mark Cust 2017;51: 52-7.
- Kwon MJ, Moon JS, Choi EY. Development of preservatives for cosmetics using herbal extracts. J Korean Soc Cosmetol 2015; 21:347-56.
- Whang WK, Lee YA. Study about the natural ingredient cosmetics purchase toward the consciousness of LOHAS and socio-populational status. Asian J Beauty Cosmetol 2010;8:191-200.
- Shim SB. The study of characteristics of cosmetic powder by using various grinding mill. JKAIS 2008;9:500-7.
- Lee KO, Lee SH. The effects of skin treatment of Kumsong (Sciadopitys verticillata) extracts. J Korean Soc Cosmetol 2007;13:1185-95.
- Jeong DH, Kang BK, Kim KBWR, Kim MJ, Ahn DH. Antiinflammatory activity of Sargassum micracanthum water extract. J Appl Biol Chem 2014;57:227-34.
- Yoon YI, Chung MY, Hwang JS, Goo TW, Ahn MY, Lee YB, et al. Anti-inflammatory effect of Oxya chinensis sinuosa ethanol extract in LPS-induced RAW 264.7 cells. J Life Sci 2014;24: 370-6.
- Cho EJ, Lee JH, Sung NY, Byun EH. Anti-Inflammatory effects of Annona muricata leaf ethanol extracts. J Korean Soc Food Sci Nutr 2017;46:681-7.
- Green LC, Wagner DA, Glogowski J, Skipper PL, Wishnok JS, Tannenbaum SR. Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids. Anal Biochem 1982;126:131-8.
- Bredt DS, Snyder SH. Transient nitric oxide synthase neurons in embryonic cerebral cortical plate, sensory
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